Specific Aldosterone Synthase Inhibition: A Potential Improvement Over Mineralocorticoid Receptor Antagonism?

نویسندگان

  • Markus P Schneider
  • Karl F Hilgers
چکیده

Specific Aldosterone Synthase Inhibition: A Potential Improvement Over Mineralocorticoid Receptor Antagonism? Markus P. Schneider, Karl F. Hilgers · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 11 Acid Test for Nitrite Pharmacology Barbora Piknova, Alan N. Schechter · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 13 SPRINT Blood Pressure: Sprinting Back to Smirk's Basal Blood Pressure? Gianfranco Parati, Juan Eugenio Ochoa, Grzegorz Bilo, Alberto Zanchetti · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 15 Putative Mechanism of Salt-Dependent Neurogenic Hypertension: Cell-Autonomous Activation of Organum Vasculosum Laminae Terminalis Neurons by Hypernatremia Patrice G. Guyenet · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 20

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Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury

Angiotensin II causes cardiovascular injury in part by aldosterone-induced mineralocorticoid receptor activation, and it can also activate the mineralocorticoid receptor in the absence of aldosterone in vitro. Here we tested whether endogenous aldosterone contributes to angiotensin II/salt-induced cardiac, vascular, and renal injury by the mineralocorticoid receptor. Aldosterone synthase knocko...

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Aldosterone and end-organ damage.

PURPOSE OF REVIEW This review highlights recent clinical studies demonstrating the contribution of aldosterone to cardiovascular mortality, vascular dysfunction, and renal injury in the context of advances in our understanding of the molecular biology of aldosterone. RECENT FINDINGS Mineralocorticoid receptor antagonism reduces mortality in patients with congestive heart failure and following...

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Spironolactone Inhibits NADPH Oxidase-Mediated Oxidative Stress and Dysregulation of the Endothelial NO Synthase in Human Endothelial Cells

Accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. NADPH oxidase has been recognized as a major source of oxidative stress in vasculature. However, the relation between NADPH oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. The present study aimed to investigate the rel...

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Spironolactone Inhibits NADPH Oxidase-Mediated Oxidative Stress and Dysregulation of the Endothelial NO Synthase in Human Endothelial Cells

Accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. NADPH oxidase has been recognized as a major source of oxidative stress in vasculature. However, the relation between NADPH oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. The present study aimed to investigate the rel...

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Specific Aldosterone Synthase Inhibition

We have come to appreciate the many physiological and pathophysiological functions of adrenal steroid hormones in health and disease and the benefits and adverse effects of therapeutic manipulations. Glucocorticoids are an indispensable component in the treatment of inflammatory conditions. Blockade of the mineralocorticoid receptor (MR) with spironolactone is a long-established diuretic therap...

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عنوان ژورنال:
  • Hypertension

دوره 69 1  شماره 

صفحات  -

تاریخ انتشار 2017